Aceclidine
The first and only aceclidine-based eye drop with potential of providing all day seamless vision for the vast majority of presbyopes.

- Made possible by aceclidine, our novel active ingredient
- Quickly achieved near vision for on demand needs with a long duration*
- No impact on distance vision in standard and night conditions*
- Potential for broadest target patient population
*Based on Phase 2
Presbyopia is the age-related loss of near vision
Problem
The lens hardens with age, limiting accommodation and shifting near vision focus

Solution
A pinhole pupil only allows light that will focus on the retina as a surrogate for accommodation

Target Pinhole Pupil Size
Research shows reducing the pupil diameter below 2mm dramatically increases depth-of-focus7

“Although differences between studies, DOF increases rapidly as the pupil diameter is reduced below 2mm”
– W. Neil Charman
Research shows reducing pupil diameter improves near vision across a broad range of lighting conditions.8

Effective Pharmacologic Treatment of Presbyopia Requires Adequate Pupil Reduction
Key side effect to avoid is the myopic shift
Risk
Triggering the iris for pinhole effect while overstimulating the ciliary muscle causing unwanted refractive change

Aceclidine
The Only Pupil Selective Miotic
Research shows aceclidine targets iris sphincter without overstimulating the ciliary muscle6

Achieving a sub 2mm pupil while uniquely avoid the myopic shift 4

Avoiding distance vision impact as limiting factor for pupil size reduction 4

Aceclidine Phase 2 INSIGHT Clinical Trial
Broad exclusivity protection
US
- 15 granted method of use and formulation patents
- 7 Patent applications under review
Ex-US
- 13 Granted method of use and formulation patents
- 33 Patent applications under review
As well as FDA exclusivity provided by New Chemical Entity status on approval.
Safety history
- Approved for Glaucoma in Europe in 1970’s6
- Approved at higher concentration and QID dosing6
- Rapid anterior chamber penetration
- Well tolerated with no tachyphylaxis
- No US DMF submission and therefore a US NCE
Aceclidine Development Progress
LNZ100 and LNZ101 are in Phase 3


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